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Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel.
Biomark Res. 2023 Jul 25;11(1):73. doi: 10.1186/s40364-023-00511-7.
Biomark Res. 2023.
PMID: 37491309
Free PMC article.
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.
Ghergurovich JM, Lang JD, Levin MK, Briones N, Facista SJ, Mueller C, Cowan AJ, McBride MJ, Rodriguez ESR, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks WPD, Espina V, Von Hoff DD, O'Shaughnessy J, Rabinowitz JD.
Ghergurovich JM, et al. Among authors: levin mk.
Med. 2021 Jun 11;2(6):736-754. doi: 10.1016/j.medj.2021.03.009. Epub 2021 Apr 14.
Med. 2021.
PMID: 34223403
Free PMC article.
Clinical Trial.
Item in Clipboard
IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer.
Wu TC, Xu K, Martinek J, Young RR, Banchereau R, George J, Turner J, Kim KI, Zurawski S, Wang X, Blankenship D, Brookes HM, Marches F, Obermoser G, Lavecchio E, Levin MK, Bae S, Chung CH, Smith JL, Cepika AM, Oxley KL, Snipes GJ, Banchereau J, Pascual V, O'Shaughnessy J, Palucka AK.
Wu TC, et al. Among authors: levin mk.
Cancer Res. 2018 Sep 15;78(18):5243-5258. doi: 10.1158/0008-5472.CAN-18-0413. Epub 2018 Jul 16.
Cancer Res. 2018.
PMID: 30012670
Free PMC article.
Clinical Trial.
Item in Clipboard
Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy.
Blas PE, Rodriguez ESR, Williams HL, Levin MK, Bell JSK, Pierobon M, Barrett AS, Petricoin EF, O'Shaughnessy JA.
Blas PE, et al. Among authors: levin mk.
Cancer Rep (Hoboken). 2024 Mar;7(3):e1954. doi: 10.1002/cnr2.1954.
Cancer Rep (Hoboken). 2024.
PMID: 38441358
Free PMC article.
Item in Clipboard
Comutation of PIK3CA and TP53 in Residual Disease After Preoperative Anti-HER2 Therapy in ERBB2 (HER2)-Amplified Early Breast Cancer.
Holmes FA, Levin MK, Cao Y, Balasubramanian S, Ross JS, Krekow L, McIntyre K, Osborne C, Espina V, Liotta L, O'Shaughnessy J.
Holmes FA, et al. Among authors: levin mk.
JCO Precis Oncol. 2019 Dec;3:1-26. doi: 10.1200/PO.18.00292.
JCO Precis Oncol. 2019.
PMID: 35100698
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Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine.
Levin MK, Wang K, Yelensky R, Cao Y, Ramos C, Hoke N, Pippen J Jr, Blum JL, Brooks B, Palmer G, Palma N, Balasubramanian S, Ross JS, O'Shaughnessy J.
Levin MK, et al.
Cancer Med. 2015 Aug;4(8):1289-93. doi: 10.1002/cam4.464. Epub 2015 Apr 13.
Cancer Med. 2015.
PMID: 25871911
Free PMC article.
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